This paper presents a low-noise and low-power transimpedance amplifier (TIA,) intended for use as an analog frontend for a very low biomedical signal detection. Different topologies are reviewed, and then the most appropriate structures are characterized. A common gate transimpedance amplifier has been designed in 0.13 μm CMOS process. Experimental results obtained show that the TIA connected to a Geiger mode photodiode with a total capacitance of 2 pF performed a bandwidth of 2.47 GHz with transimpedance gain of 53.8 and input referred current noise of 28.1 pA/(Hz) ^1/2 by using regulated cascade topology. The core circuit of the poposed analog front-end receiver occupies a chip area of 900 μm ² with power dissipation of 1.8 mW. These encouraging results have exhibited the potential of the circuit for use in the CMOS photon detector for biomedical sensing application.