A 49-residue sequence motif in the C terminus of Nav1. 9 regulates trafficking of the channel to the plasma membrane
Genetic and functional studies have confirmed an important role for the voltage-gated
sodium channel Nav1. 9 in human pain disorders. However, low functional expression of
Nav1. 9 in heterologous systems (eg in human embryonic kidney 293 (HEK293) cells) has
hampered studies of its biophysical and pharmacological properties and the development of
high-throughput assays for drug development targeting this channel. The mechanistic basis
for the low level of Nav1. 9 currents in heterologous expression systems is not understood …
sodium channel Nav1. 9 in human pain disorders. However, low functional expression of
Nav1. 9 in heterologous systems (eg in human embryonic kidney 293 (HEK293) cells) has
hampered studies of its biophysical and pharmacological properties and the development of
high-throughput assays for drug development targeting this channel. The mechanistic basis
for the low level of Nav1. 9 currents in heterologous expression systems is not understood …
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