The unmanned aerial vehicle (UAV) has drawn attention from the military and researchers worldwide, which has advantages such as robust survivability and execution ability. Mobility models are usually used to describe the movement of nodes in drone networks. Different mobility models have been proposed for different application scenarios; currently, there is no unified mobility model that can be adapted to all scenarios. The mobility of nodes is an essential characteristic of mobile ad hoc networks (MANETs), and the motion state of nodes significantly impacts the network’s performance. Currently, most related studies focus on the establishment of mathematical models that describe the motion and connectivity characteristics of the mobility models with limited universality. In this study, we use a backpropagation neural network (BPNN) to explore the relationship between the motion characteristics of mobile nodes and the performance of routing protocols. The neural network is trained by extracting five indicators that describe the relationship between nodes and the global features of nodes. Our model shows good performance and accuracy of classification on new datasets with different motion features, verifying the correctness of the proposed idea, which can help the selection of mobility models and routing protocols in different application scenarios having the ability to avoid repeated experiments to obtain relevant network performance. This will help in the selection of mobility models for drone networks and the setting and optimization of routing protocols in future practical application scenarios.