[HTML][HTML] A KSHV microRNA enhances viral latency and induces angiogenesis by targeting GRK2 to activate the CXCR2/AKT pathway
W Li, X Jia, C Shen, M Zhang, J Xu, Y Shang, K Zhu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's
sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease
(MCD). Most tumor cells in these malignancies are latently infected by KSHV. Thus, viral
latency is critical for the development of tumor and induction of tumor-associated
angiogenesis. KSHV encodes more than two dozens of miRNAs but their roles in KSHV-
induced angiogenesis remains unknown. We have recently shown that miR-K12-3 (miR-K3) …
sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castleman's disease
(MCD). Most tumor cells in these malignancies are latently infected by KSHV. Thus, viral
latency is critical for the development of tumor and induction of tumor-associated
angiogenesis. KSHV encodes more than two dozens of miRNAs but their roles in KSHV-
induced angiogenesis remains unknown. We have recently shown that miR-K12-3 (miR-K3) …
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