A MOF-based carrier for in situ dopamine delivery

A Pinna, R Migheli, G Rocchitta, PA Serra, P Falcaro… - RSC …, 2018 - pubs.rsc.org
MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing
superparamagnetic nanoparticles to assemble a new class of biocompatible particles for
magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release,
dopamine protection from oxidative damage, long-term delivery and improved drug delivery
cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo
oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and …

[PDF][PDF] A MOF-based carrier for in situ dopamine delivery

MIL-88A (Fe) MOF crystals were nucleated and grown around a polymer core containing
superparamagnetic nanoparticles to assemble a new class of biocompatible particles for
magnetophoretic drug delivery of dopamine. The carrier enabled efficient targeted release,
dopamine protection from oxidative damage, long-term delivery and improved drug delivery
cost-efficiency. After loading, dopamine was stable within the carrier and did not undergo
oxidation. Drug release monitoring via spectrofluorimetry revealed a shorter burst effect and …
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