… We sought to better understand the protective role that IFNs play in COVID-19. We … might
underlie the differential susceptibility to severe COVID-19 observed in different individuals. To …

… Importantly, the authors show that the p46 prenylated OAS1 isoform was associated with
protection from severe COVID-19 in hospitalized patients. Lastly, the authors show that the bat …

… , we wanted to determine whether horseshoe bats, the likely source of … and severe disease
in COVID-19. Moreover, the conspicuous absence of this antiviral defense in horseshoe bats …

… , we wanted to determine whether horseshoe bats, the likely source of … and severe disease
in COVID-19. Moreover, the conspicuous absence of this antiviral defense in horseshoe bats …

… 2019 (COVID-19) pandemic, and its origins can be traced to … , the antiviral sensing of CoV
dsRNA mediated by prenylated … appearing to be absent in horseshoe bats—the reservoir hosts …

… I (RIG-I), a sensor of cytoplasmic dsRNA [5,6], and suppresses … OAS1 mRNAs with the risk
of COVID-19 hospitalization [17]. … horseshoe bat (Rhinolophus sinicus), Pallas’s mastiff bat (…

… prenylation and is significantly linked with severe COVID-19 … Notably, this defense mechanism
is absent in horseshoe bats… initiated by intracellular dsRNA sensors such as MDA5, OAS-…

… ablated the CAAX-box prenylation signal in Rhinolophoidea ..… so supportive of my academic
endeavours away from home. … COVID19 pandemic, and it can be traced to horseshoe bats …

… and disease severity in COVID-19. Chemokines and cytokines are released from infected …
that resistance to infection was not due to absence or low expression of the attachment and …

… ZAP-S lacking the C-terminal domain (Fig 3A) against at least some … GBP2, GBP5 and the
dsRNA sensor OAS1 and is also required … which prenylates highly conserved cysteine (C899). …