A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism
KJ Bryant, MJ Bidgood, PW Lei, M Taberner… - Journal of Biological …, 2011 - ASBMB
Human group IIA-secreted phospholipase A 2 (sPLA 2-IIA) is an important regulator of
cytokine-mediated inflammatory responses in both in vitro and in vivo models of rheumatoid
arthritis (RA). However, treatment of RA patients with sPLA 2-IIA inhibitors shows only
transient benefit. Using an activity-impaired sPLA 2-IIA mutant protein (H48Q), we show that
up-regulation of TNF-dependent PGE 2 production and cyclooxygenase-2 (COX-2)
induction by exogenous sPLA 2-IIA in RA fibroblast-like synoviocytes (FLSs) is independent …
cytokine-mediated inflammatory responses in both in vitro and in vivo models of rheumatoid
arthritis (RA). However, treatment of RA patients with sPLA 2-IIA inhibitors shows only
transient benefit. Using an activity-impaired sPLA 2-IIA mutant protein (H48Q), we show that
up-regulation of TNF-dependent PGE 2 production and cyclooxygenase-2 (COX-2)
induction by exogenous sPLA 2-IIA in RA fibroblast-like synoviocytes (FLSs) is independent …
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