A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity

OL Patkar, AZ Mohamed, A Narayanan, K Mardon… - Scientific reports, 2021 - nature.com
While the dire cardiometabolic consequences of the hypercaloric modern 'Western'diet are
well known, there is not much information on the health impact of a high sucrose diet not
inducing weight gain. Here, we tested the hypothesis that rats reared with intermittent binge
access to sucrose in addition to normal chow would develop an inflammatory response in
brain. To test this hypothesis, we undertook serial PET/MRI scans with the TSPO ligand [18F]
DPA714 in a group of (n= 9) rats at baseline and again after voluntarily consuming 5 …

[引用][C] A binge high sucrose diet provokes systemic and cerebral inflammation in rats without inducing obesity. Sci Rep 11: 11252

OL Patkar, AZ Mohamed, A Narayanan, K Mardon… - 2021
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