A catalyst-free, one-pot multicomponent synthesis of spiro-benzimidazoquinazolinones via a Knoevenagel–Michael-imine pathway: a microwave assisted approach
RSC advances, 2016•pubs.rsc.org
A novel multi-component route for the synthesis of spiro-benzimidazoquinazolinones has
been developed under microwave irradiation. It involves a one-pot three-component
reaction of acenaphthoquinone or isatin, 1, 3-diketone and 2-aminobenzimidazole in
ethanol at 180 W and 160° C temperature. An attractive feature of this method is the mild
conditions with operational simplicity. The computational studies provide insight into the
mechanistic aspects of the reaction.
been developed under microwave irradiation. It involves a one-pot three-component
reaction of acenaphthoquinone or isatin, 1, 3-diketone and 2-aminobenzimidazole in
ethanol at 180 W and 160° C temperature. An attractive feature of this method is the mild
conditions with operational simplicity. The computational studies provide insight into the
mechanistic aspects of the reaction.
A novel multi-component route for the synthesis of spiro-benzimidazoquinazolinones has been developed under microwave irradiation. It involves a one-pot three-component reaction of acenaphthoquinone or isatin, 1,3-diketone and 2-aminobenzimidazole in ethanol at 180 W and 160 °C temperature. An attractive feature of this method is the mild conditions with operational simplicity. The computational studies provide insight into the mechanistic aspects of the reaction.
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