A combination of receptor-binding domain and N-terminal domain neutralizing antibodies limits the generation of SARS-CoV-2 spike neutralization-escape mutants

D Haslwanter, ME Dieterle, AZ Wec, CM O'brien… - Mbio, 2021 - Am Soc Microbiol
… that key mutations in the N-terminal domain can reduce the neutralizing capacity of … a
combination of two neutralizing antibodies targeting the receptor-binding and N-terminal domains

Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

F Yu, R Xiang, X Deng, L Wang, Z Yu, S Tian… - … and Targeted Therapy, 2020 - nature.com
neutralizing antibodies using the virus receptor-binding … (SP); N-terminal domain (NTD);
receptor-binding domain (RBD), … To overcome the limitations of monovalent sdAbs, 30 sdAbs …

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
… IgG Fc-domain to overcome the limitations of the monovalent … In conclusion, the discovered
neutralizing antibodies in this … with N-terminal interleukin-2 signal peptide and C-terminal Fc …

SARS-CoV-2 neutralizing antibody responses towards full-length spike protein and the receptor-binding domain

R Bayarri-Olmos, M Idorn, A Rosbjerg… - The Journal of …, 2021 - journals.aai.org
… Authorizations to two combination products, bamlanivimab … (aa 17–740) with an N-terminal
CD33 signal peptide and a dual C-… neutralization potency of mouse sera reached a maximum

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao… - Science, 2020 - science.org
… to the receptor binding domain (RBD), S1 has an N-terminal … SARS-CoV-2–neutralizing
antibodies that target the RBD and … Combination of 4A8 with RBD-targeting antibodies may avoid …

[HTML][HTML] Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies

M Yuan, H Liu, NC Wu, IA Wilson - Biochemical and biophysical research …, 2021 - Elsevier
… The S1 domain contains an N-terminal domain (NTD) and the RBD that connects to two
subdomains (SD1, SD2) at the C-terminus. The RBD transiently switches between an up state …

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

G Cerutti, Y Guo, P Wang, MS Nair, M Wang, Y Huang… - Cell reports, 2021 - cell.com
Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain
or the N-terminal domain (NTD). Over a dozen potently neutralizing NTD-directed antibodies

Antibodies to neutralising epitopes synergistically block the interaction of the receptorbinding domain of SARS‐CoV‐2 to ACE 2

M Pandey, V Ozberk, S Eskandari… - Clinical & …, 2021 - Wiley Online Library
… CP samples spanning the minimum to maximum range. … One set was produced with N-terminal
biotin, and these peptides were used with streptavidin coated ELISA plates. Another set

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

N Suryadevara, S Shrihari, P Gilchuk, LA VanBlargan… - Cell, 2021 - cell.com
antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding
domain and block … that the RBD region is a key target for potently neutralizing antibodies ( …

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

M McCallum, A De Marco, FA Lempp, MA Tortorici… - Cell, 2021 - cell.com
… contains an immunodominant receptor-binding domain (RBD) targeted by most neutralizing
antibodies (Abs) in COVID-19 patient plasma. Little is known about neutralizing Abs binding …