This study was conducted on 20 adult mice divided randomly into 4 equal groups. The first group served as negative control (NC) that received the diluent (sun flower oil), while hyperlipidemia was induced in the other three groups; the second group received the diluent and was considered as positive control (PC), while groups three and four were treated with olive oil (OO) or Nigella sativa oil (NSO) at a dose of 0.4 ml/kg BW given orally, respectively for two months. At the end of experiment and fasting overnight, lipid profile which included total cholesterol TC, triglyceride TG, high density lipoprotein cholesterol HDL-C, low density lipoprotein cholesterol LDL-C and very low density lipoprotein cholesterol VLDL-C) were measured. The results indicated significant (P< 0.05) improvement in all these parameters as compared to the positive control, while the value of HDL-C was significantly higher in the olive oil treated group as compared with all groups including negative control group.