A comprehensive germline variant and expression analyses of ACE2, TMPRSS2 and SARS-CoV-2 activator FURIN genes from the Middle East: Combating SARS …
The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly
variable in different global populations. SARS-CoV-2 uses ACE2 as a cell receptor,
TMPRSS2 protease, and FURIN peptidase to invade human cells. Here, we investigated
1,378 whole-exome sequences of individuals from the Middle Eastern populations (Kuwait,
Qatar, and Iran) to explore natural variations in the ACE2, TMPRSS2, and FURIN genes. We
identified two activating variants (K26R and N720D) in the ACE2 gene that are more …
variable in different global populations. SARS-CoV-2 uses ACE2 as a cell receptor,
TMPRSS2 protease, and FURIN peptidase to invade human cells. Here, we investigated
1,378 whole-exome sequences of individuals from the Middle Eastern populations (Kuwait,
Qatar, and Iran) to explore natural variations in the ACE2, TMPRSS2, and FURIN genes. We
identified two activating variants (K26R and N720D) in the ACE2 gene that are more …
A comprehensive germline variant and expression analyses ofACE2,TMPRSS2and SARS-CoV-2 activatorFURINgenes from the Middle East: Combating SARS …
The severity of the new COVID-19 pandemic caused by the SARS-CoV-2 virus is strikingly
variable in different global populations. SARS-CoV-2 uses ACE2 as a cell receptor,
TMPRSS2 protease, and FURIN peptidase to invade human cells. Here, we investigated
1,378 whole-exome sequences of individuals from the Middle Eastern populations (Kuwait,
Qatar, and Iran) to explore natural variations in the ACE2, TMPRSS2, and FURIN genes. We
identified two activating variants (K26R and N720D) in the ACE2 gene that are more …
variable in different global populations. SARS-CoV-2 uses ACE2 as a cell receptor,
TMPRSS2 protease, and FURIN peptidase to invade human cells. Here, we investigated
1,378 whole-exome sequences of individuals from the Middle Eastern populations (Kuwait,
Qatar, and Iran) to explore natural variations in the ACE2, TMPRSS2, and FURIN genes. We
identified two activating variants (K26R and N720D) in the ACE2 gene that are more …