A computerized test battery to study pharmacodynamic effects on the central nervous system of cholinergic drugs in early phase drug development
EP Hart, R Alvarez-Jimenez, E Davidse, RJ Doll… - JoVE (Journal of …, 2019 - jove.com
Investigating potential pharmacodynamic effects in an early phase of central nervous system
(CNS) drug research can provide valuable information for further development of new
compounds. A computerized and thoroughly validated battery of neuropsychological and
neurophysiological tests has been shown to be sensitive to detect drug-induced effects of
multiple new and existing compounds. The test battery covers the main CNS domains, which
have been shown to respond to drug effects and can be repeatedly administered following …
(CNS) drug research can provide valuable information for further development of new
compounds. A computerized and thoroughly validated battery of neuropsychological and
neurophysiological tests has been shown to be sensitive to detect drug-induced effects of
multiple new and existing compounds. The test battery covers the main CNS domains, which
have been shown to respond to drug effects and can be repeatedly administered following …
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