A controlled-release microchip

JT Santini Jr, MJ Cima, R Langer - Nature, 1999 - nature.com
… Here we report a solid-state silicon microchip that can provide controlled release of single
… We have conducted proof-of-principle release studies with a prototype microchip using gold …

Controlled-release microchips

S Sharma, AJ Nijdam, PM Sinha… - Expert Opinion on …, 2006 - Taylor & Francis
controlled-release silicon microchips that employ photolithographically defined silicon
templates for their fabrication, including microreservoir-based chips and nanoporous microchips

Microchips and controlledrelease drug reservoirs

M Staples - Wiley Interdisciplinary Reviews: Nanomedicine and …, 2010 - Wiley Online Library
This review summarizes and updates the development of implantable microchip‐containing
devices that control dosing from drug reservoirs integrated with the devices. As the expense …

Microchips as controlled drug‐delivery devices

JT Santini, Jr, AC Richards, R Scheidt… - Angewandte Chemie …, 2000 - Wiley Online Library
… The passive microchip is similar to the controlled-release microchip discussed in this
review in that the substrate contains numerous reservoirs that are filled with the drug(s) to be …

Controlled release microchip

LVV Pakalapati - 2003 - dspace.mit.edu
Microchips for constant release are not a new concept, but a controlled release chip, which
does pulsatile release at variable time intervals, is clearly more efficient and useful. The …

Implantable micro-chip for controlled delivery of diclofenac sodium

SH Lee, M Park, CG Park, BH Kim, J Lee… - … of Controlled Release, 2014 - Elsevier
… The micro-chip was made of poly(methyl … a micro-chip embedded with multiple pairs of
the micro-wells and the micro-channels of different dimensions. In this work, a single micro-chip

Microchip technology in drug delivery

JT Santini, AC Richards, RA Scheidt, MJ Cima… - Annals of …, 2000 - Taylor & Francis
… of a microchip with potential application in drug delivery was recently reported in the journal
Nature (6). The controlled release microchip … The prototype microchip is made of silicon and …

Controlled release microchips

K Daniel, HLH Duc, M Cima, R Langer - Chronopharmaceutics, 2009 - Wiley Online Library
… Both the active and the passive microchipMicroChips, Inc. is currently developing implantable
drug delivery and biosensing devices based on technology similar to the active microchip

Maskless microfabrication of thermosensitive gels using a microscope and application to a controlled release microchip

R Yoshida, K Omata, K Yamaura, M Ebata, M Tanaka… - Lab on a Chip, 2006 - pubs.rsc.org
… This method would be useful for preparing microgels at target positions in microchips, for
example as a microvalve or micropump. In this study, a controlled drug-release microchip has …

A controlled-release drug delivery system on a chip using electrolysis

PL Huang, PH Kuo, YJ Huang, HH Liao… - IEEE Transactions …, 2011 - ieeexplore.ieee.org
… For instance, implantable devices for bionic systems based on microchip technologies, such
as cochlear [4] and retina [5] implants, have shown remarkable advances in size reductions …