Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant
immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to
restrain autoimmunity in female mice. We used CRISPR-Cas9 gene editing to constrain lyn
splicing and expression, generating single-isoform LynA knockout (LynAKO) or LynBKO
mice. Autoimmune disease in total LynKO mice is characterized by production of antinuclear
antibodies, glomerulonephritis, impaired B cell development, and overabundance of …

Here, we report that the LynB splice variant of the Src-family kinase Lyn exerts a dominant
immunosuppressive function in vivo, whereas the LynA isoform is uniquely required to
restrain autoimmunity in female mice. We used CRISPR-Cas9 gene editing to constrain lyn
splicing and expression, generating single-isoform LynA knockout (LynAKO) or LynBKO
mice. Autoimmune disease in total LynKO mice is characterized by production of antinuclear
antibodies, glomerulonephritis, impaired B cell development, and overabundance of …