A facile one-pot, three component synthesis of a new series of 1, 3, 4-thiadiazines: Anticancer evaluation and molecular docking studies
S Mamidala, V Vangala, SR Peddi… - Journal of Molecular …, 2021 - Elsevier
Abstract A series of new 1, 3, 4-thiadiazines were synthesized by the conventional method of
dehydroacetic acid, thiocarbohydrazide and substituted phenacyl bromides or substituted 3-
(2-bromoacetyl) coumarins. Structures of all the synthesized compounds were confirmed by
spectral (1 H & 13 C NMR, FTIR, Mass) and analytical data. The target compounds were
screened for their in vitro anticancer activity, From the in vitro anticancer results, it was found
that the compound 6a has shown significant activity with the standard. Furthermore, the …
dehydroacetic acid, thiocarbohydrazide and substituted phenacyl bromides or substituted 3-
(2-bromoacetyl) coumarins. Structures of all the synthesized compounds were confirmed by
spectral (1 H & 13 C NMR, FTIR, Mass) and analytical data. The target compounds were
screened for their in vitro anticancer activity, From the in vitro anticancer results, it was found
that the compound 6a has shown significant activity with the standard. Furthermore, the …
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