A femtomolar-acting neuroprotective peptide.
DE Brenneman, I Gozes - The Journal of clinical …, 1996 - Am Soc Clin Investig
A novel 14-amino acid peptide, with stress-protein-like sequences, exhibiting
neuroprotection at unprecedented concentrations, is revealed. This peptide prevented
neuronal cell death associated with the envelope protein (GP 120) from HIV, with
excitotoxicity (N-methyl d-aspartate), with the beta amyloid peptide (putative cytotoxin in
Alzheimer's disease), and with tetrodotoxin (electrical blockade). The peptide was designed
to contain a sequence derived from a new neuroprotective protein secreted by astroglial …
neuroprotection at unprecedented concentrations, is revealed. This peptide prevented
neuronal cell death associated with the envelope protein (GP 120) from HIV, with
excitotoxicity (N-methyl d-aspartate), with the beta amyloid peptide (putative cytotoxin in
Alzheimer's disease), and with tetrodotoxin (electrical blockade). The peptide was designed
to contain a sequence derived from a new neuroprotective protein secreted by astroglial …
A femtomolar-acting neuroprotective peptide induces increased levels of heat shock protein 60 in rat cortical neurons: a potential neuroprotective mechanism
R Zamostiano, A Pinhasov, M Bassan, O Perl… - Neuroscience …, 1999 - Elsevier
Activity-dependent neurotrophic factor (ADNF) was recently isolated from conditioned media
of astrocytes stimulated with vasoactive intestinal peptide (VIP). ADNF provided
neuroprotection at femtomolar concentration against a wide variety of toxic insults. A nine
amino acid peptide (ADNF-9) captured with even greater potency the neuroprotective
activity exhibited by the parent protein. Utilizing Northern and Western blot analyses, it was
now shown that ADNF-9 increased the expression of heat shock protein 60 (hsp60) in rat …
of astrocytes stimulated with vasoactive intestinal peptide (VIP). ADNF provided
neuroprotection at femtomolar concentration against a wide variety of toxic insults. A nine
amino acid peptide (ADNF-9) captured with even greater potency the neuroprotective
activity exhibited by the parent protein. Utilizing Northern and Western blot analyses, it was
now shown that ADNF-9 increased the expression of heat shock protein 60 (hsp60) in rat …
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