A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to Human Papilloma Virus-related cancers

JL Espinoza, VH Nguyen, H Ichimura, TTT Pham… - Scientific reports, 2016 - nature.com
… the LNK allele of NKG2D gene in Vietnamese individuals with HPV-related cancers than in
… rs1049174 polymorphism modulates NKG2D expression and NKG2D-mediated cytotoxicity

Association of NKG2D gene variants with susceptibility and severity of rheumatoid arthritis

CM Mariaselvam, R Tamouza… - Clinical & …, 2017 - academic.oup.com
… role in modulating NK cell activation. … NK cell receptor polymorphism did not affect the
antibody production and joint erosions, we observed that NKG2D polymorphisms were associated

The biological influence and clinical relevance of polymorphism within the NKG2D ligands

J Zuo, F Mohammed, P Moss - Frontiers in immunology, 2018 - frontiersin.org
NKG2D or modulate cytotoxic activity from the target cell. In particular, ligands with high affinity
for NKG2D are associated … increased levels of NK cell cytotoxicity and cytokine production …

NKG2D natural killer cell receptor—a short description and potential clinical applications

J Siemaszko, A Marzec-Przyszlak, K Bogunia-Kubik - Cells, 2021 - mdpi.com
NKG2D receptor has an essential role in NK cell cytotoxicity … been uncovered as functional
polymorphisms: rs1049174 … Anti-NKG2D mAb can modulate the lymphocyte and intestinal …

Influence of NKG2D genetic variants on response to anti-TNF agents in patients with rheumatoid arthritis

M Iwaszko, J Świerkot, K Kolossa, S Jeka, P Wiland… - Genes, 2018 - mdpi.com
… a plausible role of polymorphisms within the NKG2D gene as a … The NKG2D rs2255336 SNP
has been shown to modulate … that NKG2D rs2255336 may contribute to determining NK cell

Inhibitory NKG2A and activating NKG2D and NKG2C natural killer cell receptor genes: susceptibility for rheumatoid arthritis

KS Park, JH Park, YW Song - Tissue antigens, 2008 - Wiley Online Library
… The function of these cells is modulated by the several … The activating receptors on NK cell
include several group with … >Thr) polymorphisms were strongly associated with susceptibility …

Genetic variants in NKG2D axis and susceptibility to Epstein–Barr virus-induced nasopharyngeal carcinoma

NH Viet, NQ Trung, LT Dong, LQ Trung… - Journal of cancer …, 2021 - Springer
… associations between functional polymorphisms in NKG2D and MICA genes with NPC … a
variant associated with lower NKG2D receptor expression and reduced NK cell cytotoxicity) and …

[HTML][HTML] NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells

BA Hussein, L Kristenson, S Pesce… - … for Immunotherapy of …, 2023 - ncbi.nlm.nih.gov
NKG2D and NKG2A gene variants on NK cell function and outcome of HDC/IL-2 immunotherapy
in AML. In summary, we found that NKC gene variants were associatedpolymorphisms

Impact of NK cell activating receptor gene variants on receptor expression and outcome of immunotherapy in acute myeloid leukemia

BA Hussein, A Hallner, L Wennström, M Brune… - Frontiers in …, 2021 - frontiersin.org
polymorphisms in the NKC gene locus affect NK cell responses to malignant cells and may
be associated … in the gene encoding NKG2D, is associated with both NKG2D expression …

Regulation of immune cell function and differentiation by the NKG2D receptor

B Zafirova, FM Wensveen, M Gulin, B Polić - Cellular and Molecular Life …, 2011 - Springer
… most polymorphic genes within the group of MHC class I-related … of reduced NKG2D affinity,
have been associated with … conclusion, NKG2D appears to play an important role in NK cell