A gain of function mutation in SlNRC4a enhances basal immunity resulting in broad-spectrum disease resistance

L Pizarro, M Leibman-Markus, R Gupta… - Communications …, 2020 - nature.com
… , acting as a gain of function of SlNRC4a. We hypothesized that slnrc4a gain of function will
lead to enhanced basal immunity, resulting in broad-spectrum pathogen and pest resistance. …

Members of the tomato NRC4 h-NLR family augment each other in promoting basal immunity

M Leibman-Markus, R Gupta, S Schuster, A Avni, M Bar - Plant Science, 2023 - Elsevier
… this slnrc4a mutant as a gain of function mutant possessing broad-spectrum disease …
whether genetically enhancing the function of SlNRC4b, or of both SlNRC4a and SlNRC4b …

Regulation of cell death and signaling by pore-forming resistosomes

G Bi, JM Zhou - Annual review of phytopathology, 2021 - annualreviews.org
… interest to engineering broad-spectrum and durable disease … PopP2-triggered immune
activation is mediated by enhanced … ADR1-L2 and NRG1 result in autoactivation and trigger cell …

Dynamin-related proteins enhance tomato immunity by mediating pattern recognition receptor trafficking

M Leibman-Markus, S Schuster, B Vasquez-Soto… - Membranes, 2022 - mdpi.com
results, we conclude that SlDRP1B regulates PRR trafficking and, therefore, plant immunity,
… we observed a threefold increase in LeEIX2 endosome size and density in basal conditions (…

Help wanted: helper NLRs and plant immune responses

LM Jubic, S Saile, OJ Furzer, F El Kasmi… - Current opinion in plant …, 2019 - Elsevier
… For instance, SlNRC4a plays a non-canonical role as a … The CNL PigmR confers broad-spectrum
resistance to M. oryzae [20]. … was significantly enhanced in comparison to the immune-…

PTI‐ETI synergistic signal mechanisms in plant immunity

XQ Yu, HQ Niu, C Liu, HL Wang… - Plant Biotechnology …, 2024 - Wiley Online Library
… of immunity, promotes PR expression upon gain of function … The slnrc4a mutant confers
broadspectrum disease resistance by … immunity resulting in broad-spectrum disease resistance. …

Signaling mechanisms underlying resistance responses: what have we learned, and how is it being applied?

A Kachroo, P Vincelli, P Kachroo - Phytopathology, 2017 - Am Phytopath Society
… level and protects against a broad spectrum of pathogens. … , resulting in nuclear gene
induction and eventually basal … serve as pathogen virulence enhancers; pathogen effectors …

The Entomopathogenic Fungi Metarhizium brunneum and Beauveria bassiana Promote Systemic Immunity and Confer Resistance to a Broad Range of Pests and …

R Gupta, R Keppanan, M Leibman-Markus… - …, 2022 - Am Phytopath Society
results indicate that EPF induce systemic plant immunity and disease resistance by activating
the plant host defense machinery, as evidenced by increases … use in broad-spectrum pest …

Arabidopsis cell surface LRR immune receptor signaling through the EDS1-PAD4-ADR1 node

RN Pruitt, L Zhang, SC Saile, D Karelina, K Fröhlich… - BioRxiv, 2020 - biorxiv.org
results of statistical tests for differences between the mutant … To test whether reduced basal
immunity is due to impaired … -type but not of a pad4 mutant enhanced LRR-RP-but not LRR-…

The LeEIX locus determines pathogen resistance in tomato

M Leibman-Markus, R Gupta, L Pizarro… - Phytopathology …, 2023 - Am Phytopath Society
… plants exhibit a general increase in basal immunity and increased resistance to a wide range
… This suggests that increases in localized immune responses could result from increases in …