A hippo and fibroblast growth factor receptor autocrine pathway in cholangiocarcinoma
SI Ilyas, D Yamada, P Hirsova, SF Bronk… - Journal of Biological …, 2016 - jbc.org
Herein, we have identified cross-talk between the Hippo and fibroblast growth factor
receptor (FGFR) oncogenic signaling pathways in cholangiocarcinoma (CCA). Yes-
associated protein (YAP) nuclear localization and up-regulation of canonical target genes
was observed in CCA cell lines and a patient-derived xenograft (PDX). Expression of
FGFR1,-2, and-4 was identified in human CCA cell lines, driven, in part, by YAP coactivation
of TBX5. In turn, FGFR signaling in a cell line with minimal basal YAP expression induced its …
receptor (FGFR) oncogenic signaling pathways in cholangiocarcinoma (CCA). Yes-
associated protein (YAP) nuclear localization and up-regulation of canonical target genes
was observed in CCA cell lines and a patient-derived xenograft (PDX). Expression of
FGFR1,-2, and-4 was identified in human CCA cell lines, driven, in part, by YAP coactivation
of TBX5. In turn, FGFR signaling in a cell line with minimal basal YAP expression induced its …
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