A leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase
Protozoa Leishmania donovani (Ld) is the main cause of the endemic disease
leishmaniasis. Spermidine synthase (SS), an important enzyme in the synthetic pathway of
polyamines in Ld, is an essential element for the survival of this protozoan. Targeting SS
may provide an important aid for the development of drugs against Ld. However, absence of
tertiary structure of spermidine synthase of Leishmania donovani (LSS) limits the
possibilities of structure based drug designing. Presence of the same enzyme in the host …
leishmaniasis. Spermidine synthase (SS), an important enzyme in the synthetic pathway of
polyamines in Ld, is an essential element for the survival of this protozoan. Targeting SS
may provide an important aid for the development of drugs against Ld. However, absence of
tertiary structure of spermidine synthase of Leishmania donovani (LSS) limits the
possibilities of structure based drug designing. Presence of the same enzyme in the host …
A leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase.
Abstract Protozoa Leishmania donovani (Ld) is the main cause of the endemic disease
leishmaniasis. Spermidine synthase (SS), an important enzyme in the synthetic pathway of
polyamines in Ld, is an essential element for the survival of this protozoan. Targeting SS
may provide an important aid for the development of drugs against Ld. However, absence of
tertiary structure of spermidine synthase of Leishmania donovani (LSS) limits the
possibilities of structure based drug designing. Presence of the same enzyme in the host …
leishmaniasis. Spermidine synthase (SS), an important enzyme in the synthetic pathway of
polyamines in Ld, is an essential element for the survival of this protozoan. Targeting SS
may provide an important aid for the development of drugs against Ld. However, absence of
tertiary structure of spermidine synthase of Leishmania donovani (LSS) limits the
possibilities of structure based drug designing. Presence of the same enzyme in the host …
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