A mathematical analysis of an activator-inhibitor Rho GTPase model
Recent experimental observations reveal that local cellular contraction pulses emerge via a
combination of fast positive and slow negative feedbacks based on a signal network
composed of Rho, GEF and Myosin interactions [22]. As an examplary, we propose to study
a plausible, hypothetical temporal model that mirrors general principles of fast positive and
slow negative feedback, a hallmark for activator-inhibitor models. The methodology involves
(i) a qualitative analysis to unravel system switching between different states (stable …
combination of fast positive and slow negative feedbacks based on a signal network
composed of Rho, GEF and Myosin interactions [22]. As an examplary, we propose to study
a plausible, hypothetical temporal model that mirrors general principles of fast positive and
slow negative feedback, a hallmark for activator-inhibitor models. The methodology involves
(i) a qualitative analysis to unravel system switching between different states (stable …
A mathematical analysis of an activator-inhibitor Rho GTPase model
Recent experimental observations reveal that local cellular contraction pulses emerge via a
combination of fast positive and slow negative feedbacks based on a signal network
composed of Rho, GEF and Myosin interactions [22]. As an examplary, we propose to study
a plausible, hypothetical temporal model that mirrors general principles of fast positive and
slow negative feedback, a hallmark for activator-inhibitor models. The methodology involves
(?) a qualitative analysis to unravel system switching between different states (stable …
combination of fast positive and slow negative feedbacks based on a signal network
composed of Rho, GEF and Myosin interactions [22]. As an examplary, we propose to study
a plausible, hypothetical temporal model that mirrors general principles of fast positive and
slow negative feedback, a hallmark for activator-inhibitor models. The methodology involves
(?) a qualitative analysis to unravel system switching between different states (stable …
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