A microfluidic high-resolution NMR flow probe
J Bart, AJ Kolkman, AJ Oosthoek-de Vries… - Journal of the …, 2009 - ACS Publications
J Bart, AJ Kolkman, AJ Oosthoek-de Vries, K Koch, PJ Nieuwland, H Janssen, J van Bentum…
Journal of the American Chemical Society, 2009•ACS PublicationsA microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is
demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in
microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was
monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great
promise for metabolomics studies, as shown by an analysis of 600 nL of human
cerebrospinal fluid.
demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in
microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was
monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great
promise for metabolomics studies, as shown by an analysis of 600 nL of human
cerebrospinal fluid.
A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.
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