A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation
Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading
frames (sORFs), but the coding capacities of these sORFs and the functions of the resulting
micropeptides remain elusive. Here, we report that human lncRNA MIR155HG encodes a 17–
amino acid micropeptide, which we termed miPEP155 (P155). MIR155HG is highly
expressed by inflamed antigen-presenting cells, leading to the discovery that P155 interacts
with the adenosine 5′-triphosphate binding domain of heat shock cognate protein 70 …
frames (sORFs), but the coding capacities of these sORFs and the functions of the resulting
micropeptides remain elusive. Here, we report that human lncRNA MIR155HG encodes a 17–
amino acid micropeptide, which we termed miPEP155 (P155). MIR155HG is highly
expressed by inflamed antigen-presenting cells, leading to the discovery that P155 interacts
with the adenosine 5′-triphosphate binding domain of heat shock cognate protein 70 …
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