A new bioactive compound from the roots of Petasites hybridus
F Khaleghi, LB Din, FR Charati, WA Yaacob… - Phytochemistry …, 2011 - Elsevier
Phytochemistry Letters, 2011•Elsevier
A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its
structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by
spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate
inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50
value of 48μmol/L. The interaction of bovine serum albumin (BSA) and DNA with compound
1 were studied in an aqueous solution under physiological conditions by UV–vis …
structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by
spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate
inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50
value of 48μmol/L. The interaction of bovine serum albumin (BSA) and DNA with compound
1 were studied in an aqueous solution under physiological conditions by UV–vis …
A new benzofuran derivative (1) was isolated from the roots of Petasites hybridus and its structure was determined as 1-(6-hydroxy-2-isopropenyl-1-benzofuran-5-yl)-1-ethanone by spectroscopic data and X-ray crystallographic analysis. The compound 1 showed moderate inhibitory activity on human breast cancer MCF-7 cells proliferation in vitro with an IC50 value of 48μmol/L. The interaction of bovine serum albumin (BSA) and DNA with compound 1 were studied in an aqueous solution under physiological conditions by UV–vis spectroscopy.
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