A new dual function orodissolvable/dispersible meclizine HCL tablet to challenge patient inconvenience: in vitro evaluation and in vivo assessment in human …
AY Darwesh, MS El-Dahhan, MM Meshali - Drug Delivery and …, 2021 - Springer
Meclizine hydrochloride (MCZ), a first-generation antihistamine of the piperazine class, is
antiemetic and intended for the management of nausea and vomiting with few adverse
effects. The introduction of orodispersible tablet (ODT) would solve the problems
encountered in the administration of this drug to pediatric, geriatric, and psychiatric patients.
It would be even more advantageous if the MCZ tablet could provoke rapid and prolonged
efficacy. Achieving concomitant rapid and prolonged drug therapeutic effects in …
antiemetic and intended for the management of nausea and vomiting with few adverse
effects. The introduction of orodispersible tablet (ODT) would solve the problems
encountered in the administration of this drug to pediatric, geriatric, and psychiatric patients.
It would be even more advantageous if the MCZ tablet could provoke rapid and prolonged
efficacy. Achieving concomitant rapid and prolonged drug therapeutic effects in …
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