A new isoxazolyl-urea derivative induces apoptosis, paraptosis, and ferroptosis by modulating MAPKs in pancreatic cancer cells
YY Jung, RN Suresh, CD Mohan, KB Harsha… - Biochimie, 2024 - Elsevier
MAPK pathway regulates the major events including cell division, cell death, migration,
invasion, and angiogenesis. Small molecules that modulate the MAPK pathway have been
demonstrated to impart cytotoxicity in cancer cells. Herein, the synthesis of a new isoxazolyl-
urea derivative (QR-4) has been described and its effect on the growth of pancreatic cancer
cells has been investigated. QR-4 reduced the cell viability in a panel of pancreatic cancer
cells with minimal effect on normal hepatocytes. QR-4 induced the cleavage of PARP and …
invasion, and angiogenesis. Small molecules that modulate the MAPK pathway have been
demonstrated to impart cytotoxicity in cancer cells. Herein, the synthesis of a new isoxazolyl-
urea derivative (QR-4) has been described and its effect on the growth of pancreatic cancer
cells has been investigated. QR-4 reduced the cell viability in a panel of pancreatic cancer
cells with minimal effect on normal hepatocytes. QR-4 induced the cleavage of PARP and …