A new method for the quantitation of propofol in human plasma: efficient solid-phase extraction and liquid chromatography/APCI-triple quadrupole mass spectrometry …
L Bajpai, M Varshney, CN Seubert… - Journal of Chromatography …, 2004 - Elsevier
Propofol (2, 6-diisopropyl phenol) is widely used for the induction and maintenance of
anesthesia. Analyses of its pharmacokinetics require simple and sensitive methods for
quantitation of propofol in human plasma. Previously reported HPLC and GC methods are
limited by cumbersome extraction steps. We describe a novel method that combines sample
preparation by solid-phase extraction (SPE) with hydrophilic–lipophilic balance cartridges
and analysis with a sensitive LC-APCI-triple quadrupole mass spectrometry (MS/MS) …
anesthesia. Analyses of its pharmacokinetics require simple and sensitive methods for
quantitation of propofol in human plasma. Previously reported HPLC and GC methods are
limited by cumbersome extraction steps. We describe a novel method that combines sample
preparation by solid-phase extraction (SPE) with hydrophilic–lipophilic balance cartridges
and analysis with a sensitive LC-APCI-triple quadrupole mass spectrometry (MS/MS) …