Background: Activation of platelets is a critical component of atherothrombosis and plays a
central role in the progression of unstable cardiovascular syndromes. Adenosine, acting
through adenosine receptors, increases intracellular cAMP levels and inhibits platelet
aggregation. The A2a adenosine receptor has already been recognized as a mediator of
adenosine‐dependent effects on platelet aggregation, and here we present a new role for
the A2b adenosine receptor (A2bAR) in this process. Methods and Results: As compared …