A novel in silico minigene vaccine based on CD4+ T-helper and B-cell epitopes of EG95 isolates for vaccination against cystic echinococcosis
EG95 oncospheral antigen plays a crucial role in Echinococcus granulosus pathogenicity.
Considering the diversity of antigen among different EG95 isolates, it seems to be an ideal
antigen for designing a universal multivalent minigene vaccine, so-called multi-epitope
vaccine. This is the first in silico study to design a construct for the development of global
EG95-based hydatid vaccine against E. granulosus in intermediate hosts. After antigen
sequence selection, the three-dimensional structure of EG95 was modeled and multilaterally …
Considering the diversity of antigen among different EG95 isolates, it seems to be an ideal
antigen for designing a universal multivalent minigene vaccine, so-called multi-epitope
vaccine. This is the first in silico study to design a construct for the development of global
EG95-based hydatid vaccine against E. granulosus in intermediate hosts. After antigen
sequence selection, the three-dimensional structure of EG95 was modeled and multilaterally …
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