A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. I. In vitro/in vivo stability of the scaffold and in vitro sensitivity of the …
YM Ju, B Yu, TJ Koob, Y Moussy… - Journal of Biomedical …, 2008 - Wiley Online Library
A new 3D porous and biostable collagen scaffold has been developed to improve the
biocompatibility of implantable glucose sensors by minimizing tissue reactions while
stimulating angiogenesis around the sensors. The novel collagen scaffold was crosslinked
using nordihydroguaiaretic acid (NDGA) to enhance biostability. NDGA‐treated collagen
scaffolds were stable without physical deformation in the subcutaneous tissue of rats for 4
weeks. In contrast, glutaraldehyde (GA)‐treated collagen scaffolds were extremely damaged …
biocompatibility of implantable glucose sensors by minimizing tissue reactions while
stimulating angiogenesis around the sensors. The novel collagen scaffold was crosslinked
using nordihydroguaiaretic acid (NDGA) to enhance biostability. NDGA‐treated collagen
scaffolds were stable without physical deformation in the subcutaneous tissue of rats for 4
weeks. In contrast, glutaraldehyde (GA)‐treated collagen scaffolds were extremely damaged …
A novel porous collagen scaffold around an implantable biosensor for improving biocompatibility. II. Long‐term in vitro/in vivo sensitivity characteristics of sensors …
YM Ju, B Yu, L West, Y Moussy… - Journal of Biomedical …, 2010 - Wiley Online Library
We have developed a new 3D porous and biostable collagen scaffold for implantable
glucose sensors. The scaffolds were fabricated around the sensors and crosslinked using
nordihydroguaiaretic acid (NDGA) or glutaraldehyde (GA) to enhance physical and
biological stability. The effect of the scaffolds on sensor function and biocompatibility was
examined during long‐term (≥ 28 days) in vitro and in vivo experiments and compared with
control bare sensors. To evaluate the effect of the sensor length on micromotion and sensor …
glucose sensors. The scaffolds were fabricated around the sensors and crosslinked using
nordihydroguaiaretic acid (NDGA) or glutaraldehyde (GA) to enhance physical and
biological stability. The effect of the scaffolds on sensor function and biocompatibility was
examined during long‐term (≥ 28 days) in vitro and in vivo experiments and compared with
control bare sensors. To evaluate the effect of the sensor length on micromotion and sensor …
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