Eukaryotic genomes are organised into complex higher-order structures within the nucleus,
and the three-dimensional arrangement of chromosomes is functionally important for global
gene regulation. The existence of supernumerary chromosome 21 in Down syndrome may
perturb the nuclear architecture at different levels, which is normally optimised to maintain
the physiological balance of gene expression. However, it has not been clearly elucidated
whether and how aberrant configuration of chromosomes affects gene activities. To …

CiNii 博士論文 - A pair of maternal chromosomes derived from meiotic nondisjunction in
trisomy 21 affects nuclear architecture and transcriptional regulation … A pair of maternal
chromosomes derived from meiotic nondisjunction in trisomy 21 affects nuclear architecture
and transcriptional regulation 減数分裂の不分離によって生じた21トリソミーの母由来の21番
染色体のペアは核内配置と転写制御に影響を与える … 減数分裂の不分離によって生じた21トリソミー
の母由来の21番染色体のペアは核内配置と転写制御に影響を与える …