A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse …
K Iwasa, S Yamamoto, K Yamashina… - Journal of …, 2021 - Springer
Background Neuroinflammation is a key pathological component of neurodegenerative
disease and is characterized by microglial activation and the secretion of proinflammatory
mediators. We previously reported that a surge in prostaglandin D 2 (PGD 2) production and
PGD 2-induced microglial activation could provoke neuroinflammation. We also reported
that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could
be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon …
disease and is characterized by microglial activation and the secretion of proinflammatory
mediators. We previously reported that a surge in prostaglandin D 2 (PGD 2) production and
PGD 2-induced microglial activation could provoke neuroinflammation. We also reported
that a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could
be activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon …
[PDF][PDF] A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD
K Iwasa, S Yamamoto, K Yamashina… - 2021 - jneuroinflammation.biomedcentral …
Background: Neuroinflammation is a key pathological component of neurodegenerative
disease and is character‑ized by microglial activation and the secretion of proinflammatory
mediators. We previously reported that a surge in prostaglandin D2 (PGD2) production and
PGD2‑induced microglial activation could provoke neuroinflammation. We also reported that
a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be
activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon …
disease and is character‑ized by microglial activation and the secretion of proinflammatory
mediators. We previously reported that a surge in prostaglandin D2 (PGD2) production and
PGD2‑induced microglial activation could provoke neuroinflammation. We also reported that
a lipid sensor GPR120 (free fatty acid receptor 4), which is expressed in intestine, could be
activated by polyunsaturated fatty acids (PUFA), thereby mediating secretion of glucagon …
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