… faced by oligonucleotides and recent advances in improving oligonucleotide drug delivery.
Further, … approach to personalized treatment for patients with rare and fatal diseases with OT. …

… patients still without prospect of disease-modifying treatments. In response to this gap, n-of-1
ASO treatment approaches … a stronger integration of patient care and clinical research when …

… with the potential to revolutionize treatment approaches [11]. An … genetic content in a patient's
cells—adding, removing, or … brids for oligonucleotide delivery are essentially customized …

… This approach enables the rapid development of customized treatments based on individual
patients’ … Antisense oligonucleotides (ASOs) represent a significant advancement in RNA …

… oligonucleotide therapeutics (OT) indicates the imminent potential of these therapies. …
emerging approach to personalized treatment for patients with rare and fatal diseases with OT. …

… With the advancement of biotechnology, therapeutic approaches have been diversified to …
network, such as health-care professionals and patients. Furthermore, longitudinal studies and …

… in patients [49]. To overcome these challenges, new studies are exploring a range of methods.
… Chemical modification of natural oligonucleotides is the major approach to ameliorate …

… oligonucleotide synthesis techniques, including phosphodiester, phosphotriester, and
phosphoramidite approaches. … synthesis of the oligonucleotide approach has been adapted for the …

… and structure, and convenient customization. Researchers have … regimen that replicates
the patient's natural daily cycle is … vertices, with the oligonucleotides attached as connectors to …