… Establishing a translational, large-animal model for therapeutic delivery to the entire …
therapeutic approaches in cardiac transplantation. The porcine, heterotopic heart transplantation …

… pigs were housed for 7 weeks under appropriate living conditions before either tissue
harvesting or heterotopic heart transplantation… pig received continued anticoagulation therapy (…

… Thus, long-term anticoagulation therapy with warfarin is necessary in patients following …
Analysis of the outcome of early cases of heterotopic porcine cardiac xenotransplants will likely …

… pig heterotopic transplant model was utilized as previously described 12 . This model was
used because the pig heart … guidance on the heterotopic heart transplant model development. …

… for standard advanced heart failure therapies. He was … genetically modified pig-to-human
cardiac xenotransplant 1 , … animal, xeno-heart transplantation might result in improved survival. …

… We describe the use CMR to screen transplanted abdominal hearts in a porcine model of
acute rejection following heart transplantation and … began immunosuppression therapy. The …

… has become a widely accepted therapeutic option for the … with congenital heart disease,
since most complex congenital heart … A heterotopic heart transplant could then act as a biologic …

… Here we used SASTG to deliver the transgene firefly luciferase to porcine allografts
during … Heterotopic heart transplantation surgery was successfully completed in four pigs (…

… pigs expressing another complement regulatory protein CD55 did not show further extended
graft survival in heterotopic cardiac pig-to-baboon transplantation, … heart transplantation, …

… remained the definitive therapy for end-stage heart failure despite its … In our pig-to-primate
cardiac xenotransplantation project we … Figure 2.3c: Thoracic heterotopic heart transplantation (…