A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium (II) barbiturate complex
Autophagy is a catabolic process for cells that can provide energy sources and allows
cancer cells to evade cell death. Therefore, studies on the combination of autophagy
inhibitors with drugs are increasing as a new treatment modality in cancer. Previously, we
reported the anti-tumor activity of a Palladium (Pd)(II) complex against different types of
cancer in vitro and in vivo. Chloroquine (CQ), the worldwide used anti-malarial drug, has
recently been focused as a chemosensitizer in cancer treatment. The aim of this study was to …
cancer cells to evade cell death. Therefore, studies on the combination of autophagy
inhibitors with drugs are increasing as a new treatment modality in cancer. Previously, we
reported the anti-tumor activity of a Palladium (Pd)(II) complex against different types of
cancer in vitro and in vivo. Chloroquine (CQ), the worldwide used anti-malarial drug, has
recently been focused as a chemosensitizer in cancer treatment. The aim of this study was to …
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