Microfluidics-based organ-on-a-chip technology allows for developing a new class of in-vitro
blood-brain barrier (BBB) models that recapitulate many hemodynamic and architectural
features of the brain microvasculature not attainable with conventional two-dimensional
platforms. Herein, we describe and validate a novel microfluidic BBB model that closely
mimics the one in situ. Induced pluripotent stem cell (iPSC)-derived brain microvascular
endothelial cells (BMECs) were juxtaposed with primary human pericytes and astrocytes in …