A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron emitting …
DY Chi, MR Kilbourn… - The Journal of …, 1987 - ACS Publications
The Journal of Organic Chemistry, 1987•ACS Publications
… In this report, we present an approach to the synthesis of fluoroalkyl amines and amides, based
on a two-step sequence involving fluoride ion displacement on a haloalkyl triflate precursor,
followed by a fluoroalkylation reaction with the resulting fluoroalkyl halide. An alternative
preparation of the fluoroalkyl … In this paper, we have described methods that permit the rapid
and efficient synthesis of 2-fluoroethyl and 3fluoropropyl amines and amides, using the two-step
process: (1) fluoride ion displacement of a haloalkyl triflate (step B-2) or olefin halofluorination …
on a two-step sequence involving fluoride ion displacement on a haloalkyl triflate precursor,
followed by a fluoroalkylation reaction with the resulting fluoroalkyl halide. An alternative
preparation of the fluoroalkyl … In this paper, we have described methods that permit the rapid
and efficient synthesis of 2-fluoroethyl and 3fluoropropyl amines and amides, using the two-step
process: (1) fluoride ion displacement of a haloalkyl triflate (step B-2) or olefin halofluorination …
Results General Strategy. As illustrated in Scheme I, one can imagine two approaches to the preparation of a fluoro-alkyl-substituted amine or amide. By the first (arrows marked with A), the amine or amide is alkylated with a
ACS Publications