Progressive phases of multiple sclerosis are associated with inhibited differentiation of the
progenitor cell population that generates the mature oligodendrocytes required for
remyelination and disease remission. To identify selective inducers of oligodendrocyte
differentiation, we performed an image-based screen for myelin basic protein (MBP)
expression using primary rat optic-nerve-derived progenitor cells. Here we show that among
the most effective compounds identifed was benztropine, which significantly decreases …

The article presents a review of the study concerning the effectiveness of the regenerative
approach in treating patients with multiple sclerosis (MS). It provides details of the study that
illustrate the impact of benztropine in enhancing remyelination compounds that stimulate
oligodendrocyte precursor cell. It also outlines the result of the study which confirms that
benztropine is more effective than fingolimod or interferon-ß in treating MS.