[HTML][HTML] A regulation loop between YAP and NR4A1 balances cell proliferation and apoptosis
L He, L Yuan, W Yu, Y Sun, D Jiang, X Wang, X Feng… - Cell reports, 2020 - cell.com
The Hippo signaling pathway maintains organ size and tissue homeostasis via orchestration
of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely
unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-
apoptotic and anti-tumor effects of the Hippo pathway whereby YAP regulates the
transcription, phosphorylation, and mitochondrial localization of NR4A1. NR4A1, in turn,
functions as a feedback inhibitor of YAP to promote its degradation, thereby inhibiting the …
of cell proliferation and apoptosis. How this pathway triggers cell apoptosis remains largely
unexplored. Here, we identify NR4A1 as a target of the Hippo pathway that mediates the pro-
apoptotic and anti-tumor effects of the Hippo pathway whereby YAP regulates the
transcription, phosphorylation, and mitochondrial localization of NR4A1. NR4A1, in turn,
functions as a feedback inhibitor of YAP to promote its degradation, thereby inhibiting the …
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