Today, coffee is the most consumed drink all around the world. It has been suggested by many researchers that consumption of coffee is associated with many health-related benefits like increasing the physical performance, lowering the risk of type 1 diabetes, Alzheimer, Parkinson’s as well as it is associated with reducing the risk of various types of cancer. It has also been noted that drinking coffee is also linked with the decreased chances of depression which is the major problem for the today’s youth. The benefits of coffee and Ganoderma are fascinating. Current study is conducted to review the benefits and the antioxidant activity of coffee and its additives. It has been proven that coffee provides the major amount of antioxidants as compared to other products like dark chocolates, cocoa, wines, fruits and vegetables. Coffee with Ganoderma is reported to have a major amount of anti-tumor as well as anti-oxidative properties as it contains triterpenoids as major bioactive compound.