The second leading reason of mortality worldwide is communicable diseases. The highly cost effective approach for disease prevention in case of communicable disease is vaccination. It is need of the hour to design and develop novel as well as safe vaccine delivery systems to safeguard against present incurable and emerging diseases. For various factors, the production of orally administered vaccines is superior to conventional injection-based formulations, including increased protection and compliance, and simplified processing and administration. In comparison, the oral route helps humoral and cellular immune responses to be activated at both systemic and mucosal sites to create larger and longer-lasting defence. This review addresses the reasoning for oral vaccines here including important biological and physicochemical implications for the design of oral vaccines for the next decade.