… In this study, we found that Ubc9 expression levels were elevated in … Ubc9 plays any role
in tumorigenesis. As a first step toward this direction, we examined the expression level of ubc9 …

… cervical cancer [26], suggesting an important role for UBC9 in viral-induced cellular
transformation. … to dissect HPV-tumorigenesis, we show that UBC9 accumulation occurs through …

… to play a role in copping with DNA damage insults. Recent reports indicate that Ubc9, the
single … which are potentially affected by Ubc9/SUMO and their role in regulating the function of …

… Given the essential role of Ubc9 in sumoylation, this review focuses on … Ubc9 function, the
potential link to tumorigenesis and drug responsiveness, as well as approaches to target Ubc9…

… Finally, using luciferase-Ubc9-3′-UTR reporters, we show that Ubc9 … Ubc9 enhances tumor
growth in the animal model (20), suggesting that Ubc9 plays a causal role in tumorigenesis. …

… allele in vivo, we used a mouse model of intestinal tumorigenesis. We crossed … role of
Ubc9 in controlling cell proliferation and tumorigenesis, we used mice haploinsufficient for Ubc9 …

… Importantly, administration of the UBC9 inhibitor 2-D08 … Together, our results demonstrate
that ablation of UBC9 could reverse … insights to halt the pathogenic process of tumorigenesis. …

… Additional studies have suggested that the Ubc9 gene may play a pivotal role in lung
tumorigenesis and may potentially serve as a biomarker for both the diagnosis and prognosis of …

… Thus, it is urgently needed to discover the associated molecular mechanisms in the
tumorigenesis and development of bladder cancer and identify potential biomarkers to improve the …

… Ubc9 (Ubc9-WT) promotes cell invasion and metastasis. Surprisingly, the dominant negative
mutant Ubc9 (Ubc9-… function of Ubc9 in cell invasion, we suppressed Ubc9 expression by …