A sex-specific role for androgens in angiogenesis

DP Sieveking, P Lim, RWY Chow, LL Dunn… - Journal of Experimental …, 2010 - rupress.org
… events in male but not female cells in vitro, and these sex-specificandrogens modulate
angiogenesis in males but not females in vivo. Moreover, in males, endogenous androgens are …

Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor …

S Yoshida, K Aihara, Y Ikeda, Y Sumitomo-Ueda… - Circulation, 2013 - Am Heart Assoc
… Therefore, sex-specific clinical and experimental data are important in delineating sex-…
Here, we show that androgen receptor activation plays an important role in angiogenesis

[HTML][HTML] Sex differences in vascular endothelial cells

J Robert - Atherosclerosis, 2023 - Elsevier
androgen levels are also at risk of cardiovascular diseases [4]. In the present review, I discuss
the current knowledge on the role … -dependent vasodilation, angiogenesis and endothelial …

Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner

B Hayward-Piatkovskyi, CR Gonyea… - American Journal …, 2023 - journals.physiology.org
… We identified sex-specific phenotypes in angiogenesis where male HPMECs produce fewer
… and testosterone play a role in sex-specific signaling and are expected to have some role in …

A Sex-Specific Role for Androgens in Angiogenesis

DP Sieveking, P Lim, RW Chow, LL Dunn, S Bao… - 2009 - Am Heart Assoc
… of various angiogenic/progenitor cells. Our findings suggest … androgens play an important
role in angiogenesis in males but not females, with implications for the role of androgen

[HTML][HTML] Androgens and androgen receptors as determinants of vascular sex differences across the lifespan

AK Lucas-Herald, RM Touyz - Canadian Journal of Cardiology, 2022 - Elsevier
sex-specific effects of androgens, heterogeneity of the vascular endothelium, differential
expression of androgen … as enhancing postischemic vascular repair by promoting angiogenesis. …

Roles of the androgenandrogen receptor system in vascular angiogenesis

S Yoshida, Y Ikeda, K Aihara - Journal of Atherosclerosis and …, 2016 - jstage.jst.go.jp
… of the protective effects of androgens against CVDs. Analysis of the androgen receptor (AR)
in … and demonstrated that the androgen–AR system plays important roles in cardiovascular …

The role of sex steroids in angiogenesis

YT Lam, L Lecce, CA Bursill, MKC Ng - … Implications of Angiogenesis, 2017 - Springer
… that AR-mediated androgen responses seem to be sex-specific, the AR itself regulates
angiogenesis independent of gender. Loss of total AR impairs angiogenesis in both male and …

Clinical efficacy and safety of angiogenesis inhibitors: sex differences and current challenges

A Cignarella, GP Fadini, C Bolego… - Cardiovascular …, 2022 - academic.oup.com
… Sex steroids, such as androgens, progestins, and oestrogens and their receptors (ERα, … a
role in the sex-specific therapeutic efficacy, safety profile and adverse effects of angiogenesis

[HTML][HTML] Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner

B Hayward-Piatkovskyi, CR Gonyea… - American Journal of …, 2022 - pmc.ncbi.nlm.nih.gov
… We identified sex-specific phenotypes in angiogenesis where male HPMECs produce fewer
… and testosterone play a role in sex-specific signaling and are expected to have some role in …