A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors

F Moradi Kashkooli, M Souri, J Tavakkoli… - Drug Delivery, 2023 - Taylor & Francis
Focused Ultrasound (FUS)-triggered nano-sized drug delivery, as a smart stimuli-responsive
system for treating solid tumors, is computationally investigated to enhance localized
delivery of drug and treatment efficacy. Integration of thermosensitive liposome (TSL), as a
doxorubicin (DOX)-loaded nanocarrier, and FUS, provides a promising drug delivery
system. A fully coupled partial differential system of equations, including the Helmholtz
equation for FUS propagation, bio-heat transfer, interstitial fluid flow, drug transport in tissue …

A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors

MC Kolios, F Moradi Kashkooli, M Souri, JJ Tavakkoli - rshare.library.torontomu.ca
Focused Ultrasound (FUS)-triggered nano-sized drug delivery, as a smart stimuli-responsive
system for treating solid tumors, is computationally investigated to enhance localized
delivery of drug and treatment efficacy. Integration of thermosensitive liposome (TSL), as a
doxorubicin (DOX)-loaded nanocarrier, and FUS, provides a promising drug delivery
system. A fully coupled partial differential system of equations, including the Helmholtz
equation for FUS propagation, bio-heat transfer, interstitial fluid flow, drug transport in tissue …
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