This study developed a stability-indicating reversed-phase HPLC method for the
simultaneous determination of morphine sulfate and naltrexone hydrochloride content in
bulk, Solid dosage forms and in-vitro dissolution samples to support product development
and quality control efforts. Chromatographic separation of the pharmaceutical compound
was achieved on a perfectSil™ MZ C18 column (250× 4.6 mm, 5 μm) with an isocratic
mobile phase composed of a mixture of acetate buffer (10 mM, pH 4, containing 0.1% of 1 …