* Corresponding author’s Email: pmehrabani@ gmail. com ABSTRACT: The aim of this study was to investigate the prevalence of cancer disease based on cancer registry data in Hormozgan province during 2011. A descriptive study conducted between all the cancer patients who referred to hospitals in Hormozgan province, south of Iran during 2011. Age-standardized incidence (ASR) and CIR were calculated by estimation for the population. The frequency and prevalence were recorded and coded using International Classification for Disease for Oncology (ICD-O). Percent frequency was reported and chi-square test was used for comparison between groups. 392 cases of cancer were recorded including 180 women (45%) and 212 men. The incidence of cancer was 24.69 and in two genders were 25.4 and 23.4 in 100,000, respectively. The most prevalent cancers between men and women were gastrointestinal and breast cancer, respectively. More than half of all cancers were reported in subjects older than 55 years. Gastrointestinal and breast cancer were more prevalent between men and women, respectively.