As rapid brain development occurs during the neonatal period, environmental manipulation
during this period may have a significant impact on sleep and memory functions. Moreover,
rapid eye movement (REM) sleep plays an important role in integrating new information with
the previously stored emotional experience. Hence, the impact of early maternal separation
and isolation stress (MS) during the stress hyporesponsive period (SHRP) on fear memory
retention and sleep in rats were studied. The neonatal rats were subjected to maternal …

As rapid brain development occurs during the neonatal period, environmental manipulation
during this period may have a significant impact on sleep and memory functions. Moreover,
Rapid Eye Movement (REM) sleep plays an important role in integrating new information
with the previously stored emotional experience. Hence, the impact of early maternal
separation and isolation stress (MS) during the stress hyporesponsive period (SHRP) on
fear memory retention and sleep in rats were studied.