A thermodynamic approach for the targeting of nucleic acid structures using their complementary single strands
The main focus of our investigations is to further our understanding of the physicochemical
properties of nucleic acid structures. We report on a thermodynamic approach to study the
reaction of a variety of intramolecular nucleic acid structures with their respective
complementary strands. Specifically, we have used a combination of isothermal titration
(ITC) and differential scanning calorimetry (DSC) and spectroscopy techniques to determine
standard thermodynamic profiles for the reaction of a triplex, G-quadruplex, hairpin loops …
properties of nucleic acid structures. We report on a thermodynamic approach to study the
reaction of a variety of intramolecular nucleic acid structures with their respective
complementary strands. Specifically, we have used a combination of isothermal titration
(ITC) and differential scanning calorimetry (DSC) and spectroscopy techniques to determine
standard thermodynamic profiles for the reaction of a triplex, G-quadruplex, hairpin loops …
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