[HTML][HTML] APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The
APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer's and cardiovascular
diseases. Although APOE has recently been associated with increased susceptibility to
infections of several viruses, whether and how APOE and its isoforms affect SARS-CoV-2
infection remains unclear. Here, we show that serum concentrations of APOE correlate
inversely with levels of cytokine/chemokine in 73 COVID-19 patients. Utilizing multiple …
APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer's and cardiovascular
diseases. Although APOE has recently been associated with increased susceptibility to
infections of several viruses, whether and how APOE and its isoforms affect SARS-CoV-2
infection remains unclear. Here, we show that serum concentrations of APOE correlate
inversely with levels of cytokine/chemokine in 73 COVID-19 patients. Utilizing multiple …
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